If you’re requesting several hundred channels at once, you may also run into issues due to URL size. For polling >100 channels, it’ll be best practice to limit yourself to a max of 100 at a time, as while Kraken may allow you to put an unlimited number (up until it breaks URL size limits) and page through the results, that endpoint is deprecated and Helix limits you to 100 ID’s or Logins per request so you’d have to split it up into multiple requests anyway.
As Barry mentioned, Webhooks are also something to consider depending on your use case.