Failed to establish a new connection: [Errno 110] Connection timed out

You are having DNS or name resoutions issues or route issues between your server and/or the API

This is either a your server, your provider or a fastly issue (faslty being the CDN in front of the API)

Theres no simple fix as it’s not a twitch issue and fiddiling with your servers settings can result in other issues

Such a thing can and will happen with any API not just Twitch